Arch Pathol Lab Med 1995; 119:1038-1043.
Detection and Monitoring of a Concomitant Atypical Myeloproliferative
Disorder and Chronic Lymphocytic Leukemia by Flow Cytometric Immunophenotyping
J. Philip McCoy, Jr, Ph.D., Elizabeth Johnson, M.D., Edison Catalano, M.D.,
Linda Blumstein, M.T. (ASCP), W. Roy Overton, Ph.D., Jeff Gryn, M.D., and
Milton H. Donaldson, M.D.
- Objective. - To illustrate the utility of a broad panel of monoclonal
antibodies to detect secondary processes or unexpected characteristics of the
primary blood dyscrasia
- Design. - Case report and discussion.
- Setting. - Regional academic medical center.
- Patient. - A sixty four year old male presenting with an apparent acute
myeloid leukemia.
- Interventions. - Sequential immunophenotyping with a broad panel of
monoclonal antibodies to monitor progression of disease and response to
therapy.
- Main outcome measure. - Identification and monitoring of the two atypical
populations in this patient with correlation to the clinical status of the
patient.
- Results. - Identification of an unsuspected mature lymphoid clone and
characterization of the evolution of the myelomonocytic clone.
- Conclusion. - The evolving mature lymphoid clone may have been overlooked
in the context of a predominant atypical myeloproliferative process,
particularly if a limited panel of monoclonal antibodies had been used for
immunophenotyping. Sequential immunophenotyping was useful in monitoring the
progression of each atypical process.